Perioral dermatitis is a common inflammatory skin condition that causes a red, bumpy, or scaly rash around the mouth, often forming clusters of small papules or pustules while typically sparing the lips. The rash may also extend to the nose or around the eyes, which is why the broader term periorificial dermatitis is sometimes used. Patients often report dryness, mild burning, tightness, or itching. Although benign, the condition can be persistent and cosmetically frustrating.

Perioral dermatitis most commonly affects women ages 20–50 but can also occur in men and children. The exact cause is unclear, though common triggers include prolonged use of topical corticosteroids, heavy facial creams or cosmetics, fluorinated toothpaste, hormonal changes, and skin-care practices that disrupt the skin barrier. Diagnosis is usually clinical, and treatment focuses on eliminating triggers, restoring the skin barrier, and using topical or oral antibiotics.